Erythroid cell maturation and hemoglobin synthesis in megaloblastic anemia.
نویسندگان
چکیده
منابع مشابه
Protein synthesis in human reticulocytes induced by therapy of megaloblastic anemia.
By EDWARD R. Bum & AND PAui. A. MARKS A CHARACTERISTIC OF THE RESPONSE to initial replacement therapy in patients with nutritional macrocytic anemia is an increase in peripheral blood reticulocytes.1 The rapid appearance of these cells in the circulation suggests the release of a relatively homogenous group of erythroid cells from the bone marrow. Their subsequent disappearance is consistent wi...
متن کاملUSE OF MYELOPEROXIDASE INDEX AS A SUITABLE TOOL TO MONITOR RESPONSE TO THERAPY IN PATIENTS WITH MEGALOBLASTIC ANEMIA
Repeated bone marrow examination was found to be of value in assessing response to treatment in megaloblastic anemia. The objective of this study was monitoring the response of megaloblastics to treatment, concerning the location of neutrophilic myeloperoxidase and myeloperoxidase index (MPXI) and their variation in megaloblastic erythroid progeny. It is possible to follow up megaloblastic ...
متن کاملArsenic intoxication as a cause of megaloblastic anemia.
We have described a case of chronic arsenic intoxication associated with pancytopenia and megaloblastic erythropoiesis. The patient had the typical laboratory manifestations of effective erythorpoiesis due to a megaloblastic process, including macroovalocytes, mild pancytopenia, low reticulocyte index, increased marrow cellularity with erythroid hyperplasia, and morphologic evidence of megalobl...
متن کاملMegaloblastic anaemia, diabetes and deafness in a 2-year-old child.
Her haemoglobin concentration was 5.4 g/dl, the mean cell volume 101 fl, and the corrected reticulocyte count 1.4%. There were oval macrocytes on the blood smear. Red cell folate and serum vitamin B12 levels were normal. Her bone marrow aspirate was hypercellular with predominantly erythroid hyperplasia and trilineage megaloblastic dysplasia. An iron stain showed numerous ringed sideroblasts (2...
متن کاملSerum erythropoietin (EST) titers in anemia.
Erythropoietin (ESF) titers were determined in sera from patients with different types of anemia using the fetal mouse liver cell bioassay. An inverse relationship was found between hemoglobin concentration and ESF titer. However, ESF titers differed markedly between patients at comparable degrees of anemia. Several groups of patients were distinguished on the basis of the activity of their ery...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 41 شماره
صفحات -
تاریخ انتشار 1962